Effect of Picrorhiza Kurroa Benth. in Acute Inflammation
نویسندگان
چکیده
The effect of the indigenous drug Picrorhiza kurrooa Benth was studied on experimental acute inflammation in rats. It was observed that Picrorhiza kurrooa at a dose of 100 mg/kg b.w. has significant (p<0.01) anti inflammatory effect with respect to control, vehicle and standard drug.
منابع مشابه
Immunopharmacological studies on Picrorhiza kurroa Royle-ex-Benth. Part III: Adrenergic mechanisms of anti-inflammatory action.
Nature of adrenergic mechanisms contributing to anti-inflammatory effect of Picrorhiza kurroa suggested from earlier studies was explored in Wistar albino rats. Water soluble fraction of alcoholic extract of rhizomes (PK) potentiated castor oil-catharsis on oral administration but direct subplanter PK-injections failed to exhibit any local irritancy and oedema. Propranolol pretreatment countera...
متن کاملPicrosides content in the rhizomes of Picrorhiza kurroa Royle ex Benth. traded for herbal drugs in the markets of North India
Picrorhiza kurroa Royle ex. Benth (Kutki) is an important medicinal plant used in various herbal drug formulations possessing hepatoprotective activity. Herbal drug industries purchase the raw plant material (dried rhizomes) of P. kurroa from the markets by judging the quality mainly on the basis of physical appearance of the rhizomes rather than the contents of active constituents. This study ...
متن کاملCardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats.
Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed significant change, however, isoproterenol (ISP) administration resulted in hemodynamic and left ventricular dysfunction, oxidative stress, and lipid peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment. Pre-treatment significantly attenuated the ISP-induced oxidative st...
متن کاملImmunopharmacological studies on Picrorhiza kurroa Royle-ex-Benth. Part IV: Cellular mechanisms of anti-inflammatory action.
In this work abroagation of anti-inflammatory effect of Picrorhiza kurroa extract (PK) by beta-adrenergic blockade was confirmed, which suggests alteration in cell-surface biology by PK treatment. Blockade of protein synthesis by cycloheximide pretreatment reduced PK effect, suggesting protein mediation. Metabolic inhibitor dinitrophenol inhibited inflammatory cedema equally in control and PK t...
متن کاملA study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease
As a major organ of intermediary metabolism, the liver is exposed to a variety of metabolic insults due to diseases and xenobiotics viz., insulin resistance (IR) drugs, toxins, microbial products, etc. One of the consequences of these metabolic insults including obesity and type 2 diabetes mellitus is the development of non-alcoholic fatty liver disease (NAFLD). The recent alarming increase in ...
متن کامل